StructureFold: genome-wide RNA secondary structure mapping and reconstruction in vivo.

ABSTRACT:

Motivation

RNAs fold into complex structures that are integral to the diverse mechanisms underlying RNA regulation of gene expression. Recent development of transcriptome-wide RNA structure profiling through the application of structure-probing enzymes or chemicals combined with high-throughput sequencing has opened a new field that greatly expands the amount of in vitro and in vivo RNA structural information available. The resultant datasets provide the opportunity to investigate RNA structural information on a global scale. However, the analysis of high-throughput RNA structure profiling data requires considerable computational effort and expertise.

Results

We present a new platform, StructureFold, that provides an integrated computational solution designed specifically fo

SUBMITTER: Tang Y 

PROVIDER: S-EPMC6280868 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature