Longitudinal Assessment of Retinal Structure in Achromatopsia Patients With Long-Term Follow-up.

ABSTRACT:

Purpose

To longitudinally characterize structural retinal changes in achromatopsia (ACHM) over extended follow-up.

Methods

Fifty molecularly confirmed ACHM subjects underwent serial spectral-domain optical coherence tomography (SD-OCT) and fundus autofluorescence (FAF) imaging. Foveal structure on SD-OCT was graded and compared for evidence of progression, and foveal total retinal thickness (FTRT) and outer nuclear layer (ONL) thickness were serially measured. FAF patterns were characterized and compared over time.

Results

Mean SD-OCT follow-up was 61.6 months (age range at baseline, 6-52 years). Forty-five of the subjects had serial FAF (mean follow-up: 48.5 months). Only 6 (12%) of the subjects demonstrated qualitative change on serial foveal SD-OCT scans. Among the

SUBMITTER: Hirji N 

PROVIDER: S-EPMC6280917 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature