Lipid metabolic networks, Mediterranean diet and cardiovascular disease in the PREDIMED trial.

ABSTRACT:

Background

Perturbed lipid metabolic pathways may play important roles in the development of cardiovascular disease (CVD). However, existing epidemiological studies have focused more on discovering individual lipid metabolites for CVD risk prediction rather than assessing metabolic pathways.

Methods

This study included a subcohort of 787 participants and all 230 incident CVD cases from the PREDIMED trial. Applying a network-based analytical method, we identified lipid subnetworks and clusters from a global network of 200 lipid metabolites and linked these subnetworks/clusters to CVD risk.

Results

Lipid metabolites with more double bonds clustered within one subnetwork, whereas lipid metabolites with fewer double bonds clustered within other subnetworks. We identified

SUBMITTER: Wang DD 

PROVIDER: S-EPMC6280948 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature