Circulating cotinine concentrations and lung cancer risk in the Lung Cancer Cohort Consortium (LC3).

ABSTRACT:

Background

Self-reported smoking is the principal measure used to assess lung cancer risk in epidemiological studies. We evaluated if circulating cotinine-a nicotine metabolite and biomarker of recent tobacco exposure-provides additional information on lung cancer risk.

Methods

The study was conducted in the Lung Cancer Cohort Consortium (LC3) involving 20 prospective cohort studies. Pre-diagnostic serum cotinine concentrations were measured in one laboratory on 5364 lung cancer cases and 5364 individually matched controls. We used conditional logistic regression to evaluate the association between circulating cotinine and lung cancer, and assessed if cotinine provided additional risk-discriminative information compared with self-reported smoking (smoking status, smoking int

SUBMITTER: Larose TL 

PROVIDER: S-EPMC6280953 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature