Functional Conservation and Divergence of daf-22 Paralogs in Pristionchus pacificus Dauer Development.

ABSTRACT: Small-molecule signaling in nematode dauer formation has emerged as a major model to study chemical communication in development and evolution. Developmental arrest as nonfeeding and stress-resistant dauer larvae represents the major survival and dispersal strategy. Detailed studies in Caenorhabditis elegans and Pristionchus pacificus revealed that small-molecule communication changes rapidly in evolution resulting in extreme structural diversity of small-molecule compounds. In C. elegans, a blend of ascarosides constitutes the dauer pheromone, whereas the P. pacificus dauer pheromone includes additional paratosides and integrates building blocks from diverse primary metabolic pathways. Despite this complexity of small-molecule structures and functions, little is known about the biosynthes

SUBMITTER: Markov GV 

PROVIDER: S-EPMC6281044 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature