Prescription Opioid Use and Risk of Coronary Heart Disease, Stroke, and Cardiovascular Death Among Adults from a Prospective Cohort (REGARDS Study).

ABSTRACT:

Objective

Despite unknown risks, prescription opioid use (POU) for nonmalignant chronic pain has grown in the US over the last decade. The objective of this study was to examine associations between POU and coronary heart disease (CHD), stroke, and cardiovascular disease (CVD) death in a large cohort.

Design, setting, subjects

POU was assessed in the prospective cohort study of 29,025 participants of the REasons for Geographic and Racial Differences in Stroke study, enrolled between 2003 and 2007 from the continental United States and followed through December 31, 2010. CHD, stroke, and CVD death were expert adjudicated outcome measures.

Methods

Cox proportional hazards models adjusted for CVD risk factors were used.

Results

Over a median (SD) of 5.2 (1.8) year

SUBMITTER: Khodneva Y 

PROVIDER: S-EPMC6281131 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature