Involvement of CD8+ T cell subsets in early response to vascular injury in patients with peripheral artery disease in vivo.

ABSTRACT:

Aims

Adaptive immunity is critical in vascular remodelling following arterial injury. We hypothesized that acute changes in T cells at a percutaneous transluminal angioplasty (PTA) site could serve as an index of their potential interaction with the injured vascular wall.

Methods and results

T cell subsets were characterised in 45 patients with Rutherford 3-4 peripheral artery disease (PAD) undergoing PTA. Direct angioplasty catheter blood sampling was performed before and immediately after the procedure. PTA was associated with an acute reduction of α/β-TcR CD8+ T cells. Further characterisation revealed significant reduction in pro-atherosclerotic CD28nullCD57+ T cells, effector (CD45RA+CCR7-) and effector memory (CD45RA-CCR7-) cells, in addition to cells bearing activatio

SUBMITTER: Maga P 

PROVIDER: S-EPMC6281164 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature