Distinct genes and pathways associated with transcriptome differences in early cardiac development between fast- and slow-growing broilers.

ABSTRACT: Modern fast-growing broilers are susceptible to cardiac dysfunctions because their relatively small hearts cannot adequately meet the increased need of pumping blood through a large body mass. To improve cardiac health in broilers through breeding, we need to identify the genes and pathways that contribute to imbalanced cardiac development and occurrence of heart dysfunction. Two broiler lines-Ross 708 and Illinois-were included in this study as models of modern fast-growing and heritage slow-growing broilers, respectively. The left ventricular transcriptome were compared between the two broiler lines at day 6 and 21 post hatch through RNA-seq analysis to identify genes and pathways regulating compromised cardiac development in modern broilers. Number of differentially expressed genes (DEG

SUBMITTER: Zhang J 

PROVIDER: S-EPMC6281182 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature