Aerosol exposure to intermediate size Nipah virus particles induces neurological disease in African green monkeys.

ABSTRACT: Nipah virus (NiV) infection can lead to severe respiratory or neurological disease in humans. Transmission of NiV has been shown to occur through contact with virus contaminated fomites or consumption of contaminated food. Previous results using the African green monkey (AGM) model of NiV infection identified aspects of infection that, while similar to humans, don't fully recapitulate disease. Previous studies also demonstrate near uniform lethality that is not consistent with human NiV infection. In these studies, aerosol exposure using an intermediate particle size (7μm) was used to mimic potential human exposure by facilitating virus deposition in the upper respiratory tract. Computed tomography evaluation found some animals developed pulmonary parenchymal disease including consolidatio

SUBMITTER: Hammoud DA 

PROVIDER: S-EPMC6281276 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature