Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure.

ABSTRACT: Systemic blood pressure is determined, in part, by arterial smooth muscle cells (myocytes). Several Transient Receptor Potential (TRP) channels are proposed to be expressed in arterial myocytes, but it is unclear if these proteins control physiological blood pressure and contribute to hypertension in vivo. We generated the first inducible, smooth muscle-specific knockout mice for a TRP channel, namely for PKD2 (TRPP1), to investigate arterial myocyte and blood pressure regulation by this protein. Using this model, we show that intravascular pressure and α₁-adrenoceptors activate PKD2 channels in arterial myocytes of different systemic organs. PKD2 channel activation in arterial myocytes leads to an inward Na⁺ current, membrane depolarization and vasoconstriction. Indu

SUBMITTER: Bulley S 

PROVIDER: S-EPMC6281320 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature