The effect of non-coding DNA variations on P53 and cMYC competitive inhibition at cis-overlapping motifs.

ABSTRACT: Non-coding DNA variations play a critical role in increasing the risk for development of common complex diseases, and account for the majority of SNPs highly associated with cancer. However, it remains a challenge to identify etiologic variants and to predict their pathological effects on target gene expression for clinical purposes. Cis-overlapping motifs (COMs) are elements of enhancer regions that impact gene expression by enabling competitive binding and switching between transcription factors. Mutations within COMs are especially important when the involved transcription factors have opposing effects on gene regulation, like P53 tumor suppressor and cMYC proto-oncogene. In this study, genome-wide analysis of ChIP-seq data from human cancer and mouse embryonic cells identified a signif

SUBMITTER: Kin K 

PROVIDER: S-EPMC6281388 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature