Elevated serum interleukin-10 at time of hospital admission is predictive of mortality in patients with Staphylococcus aureus bacteremia.

ABSTRACT:

Background

Staphylococcus aureus bacteremia (SaB) carries considerable morbidity and mortality. We examined the predictive value of serum concentrations of interleukin (IL)-10, proinflammatory cytokines, and terminal complement on patient survival and SaB duration.

Methods

Clinical information on consecutive patients with SaB at a tertiary medical center were collected prospectively. Patient serum samples obtained at the day of clinical presentation were assayed for tumor necrosis factor-α, IL-1β, IL-10, and complement membrane attack complex C5b-9 concentrations using enzyme-linked immunoassay. Logistic regression identified predictors of mortality and duration of bacteremia.

Results

In 59 patients with SaB, 14% died and 17% had prolonged bacteremia (>4 days). Elevat

SUBMITTER: Rose WE 

PROVIDER: S-EPMC6281403 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature