Decreased levels of regulatory B cells in patients with acute pancreatitis: association with the severity of the disease.

ABSTRACT: Early stratification of the severity of acute pancreatitis (AP) is clinically important. Regulatory B cells have been found to be associated with disease activity of autoimmune diseases. However, the role of Regulatory B cells in AP remains unknown. We investigate the dynamic longitudinal changes in circulating IL-10-producing B cells (B10) and memory CD19⁺CD24^hiCD27^hi cells in patients with AP to evaluate their prediction utility for AP severity. B10, CD19⁺CD24^hiCD27^hi cells, inflammatory markers and cytokines were detected in patients with AP immediately after admission to the hospital (day 1), then on the third and seventh days. We observed decreases in lymphocytes, CD19⁺, B10, CD19⁺CD24^hi

SUBMITTER: Qiu L 

PROVIDER: S-EPMC6281415 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature