Differential gene expression in human tissue resident regulatory T cells from lung, colon, and blood.

ABSTRACT: As we learn more about how immune responses occur in situ, it is becoming clear that each organ/tissue is characterized with its own anatomy and microenvironment which may affect and even determine the outcome of the immune responses. With emerging data from animal studies showing that regulatory T cells infiltrating non-lymphoid tissues exhibit unique phenotypes and transcriptional signatures and display functions beyond their well-established suppressive roles, there is an urgent need to explore the function of tissue Treg cells in humans. Here we characterized the transcriptome of Treg residing at the human mucosal tissue obtained from the normal area of cancer resections and their peripheral blood counterparts, identifying human lung and colon tissue Treg signature genes and the

SUBMITTER: Niedzielska M 

PROVIDER: S-EPMC6281418 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature