Validation of the physiological background correction method for the suppression of the spill-in effect near highly radioactive regions in positron emission tomography.

ABSTRACT:

Background

Positron emission tomography (PET) imaging has a wide applicability in oncology, cardiology and neurology. However, a major drawback when imaging very active regions such as the bladder is the spill-in effect, leading to inaccurate quantification and obscured visualisation of nearby lesions. Therefore, this study aims at investigating and correcting for the spill-in effect from high-activity regions to the surroundings as a function of activity in the hot region, lesion size and location, system resolution and application of post-filtering using a recently proposed background correction technique. This study involves analytical simulations for the digital XCAT2 phantom and validation acquiring NEMA phantom and patient data with the GE Signa PET/MR scanner. Reconstruction

SUBMITTER: Akerele MI 

PROVIDER: S-EPMC6281548 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature