Ontology highlight
ABSTRACT:
SUBMITTER: Zhang P
PROVIDER: S-EPMC6281568 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Zhang Panpan P He Qiuping Q Lei Yuan Y Li Yingqin Y Wen Xin X Hong Mengzhi M Zhang Jian J Ren Xianyue X Wang Yaqin Y Yang Xiaojing X He Qingmei Q Ma Jun J Liu Na N
Cell death & disease 20181205 12
Nasopharyngeal carcinoma (NPC) progression is regulated by genetic, epigenetic, and epitranscript modulation. As one of the epitranscript modifications, the role of N6-Methyladenosine (m<sup>6</sup>A) has not been elucidated in NPC. In the present study, we found that the poorly methylated gene ZNF750 (encoding zinc finger protein 750) was downregulated in NPC tumor tissues and cell lines. Ectopic expression of ZNF750 blocked NPC growth in vitro and in vivo. Further studies revealed that m<sup>6 ...[more]