Therapeutic faecal microbiota transplantation controls intestinal inflammation through IL10 secretion by immune cells.

ABSTRACT: Alteration of the gut microbiota has been associated with different gastrointestinal disorders. Normobiosis restoration by faecal microbiota transplantation (FMT) is considered a promising therapeutic approach, even if the mechanisms underlying its efficacy are at present largely unknown. Here we sought to elucidate the functional effects of therapeutic FMT administration during experimental colitis on innate and adaptive immune responses in the intestinal mucosa. We show that therapeutic FMT reduces colonic inflammation and initiates the restoration of intestinal homeostasis through the simultaneous activation of different immune-mediated pathways, ultimately leading to IL-10 production by innate and adaptive immune cells, including CD4⁺ T cells, iNKT cells and Antigen Presenti

SUBMITTER: Burrello C 

PROVIDER: S-EPMC6281577 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature