Loss of the candidate tumor suppressor ZEB1 (TCF8, ZFHX1A) in Sezary syndrome.

ABSTRACT: Cutaneous T-cell lymphoma is a group of incurable extranodal non-Hodgkin lymphomas that develop from the skin-homing CD4⁺ T cell. Mycosis fungoides and Sézary syndrome are the most common histological subtypes. Although next-generation sequencing data provided significant advances in the comprehension of the genetic basis of this lymphoma, there is not uniform consensus on the identity and prevalence of putative driver genes for this heterogeneous group of tumors. Additional studies may increase the knowledge about the complex genetic etiology characterizing this lymphoma. We used SNP6 arrays and GISTIC algorithm to prioritize a list of focal somatic copy-number alterations in a dataset of multiple sequential samples from 21 Sézary syndrome patients. Our results confirmed a prev

SUBMITTER: Caprini E 

PROVIDER: S-EPMC6281581 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature