Ontology highlight
ABSTRACT:
SUBMITTER: Fiore A
PROVIDER: S-EPMC6281604 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Nature communications 20181205 1
Immunosuppression is a hallmark of tumor progression, and treatments that inhibit or deplete monocytic myeloid-derived suppressive cells could promote anti-tumor immunity. c-FLIP is a central regulator of caspase-8-mediated apoptosis and necroptosis. Here we show that low-dose cytotoxic chemotherapy agents cause apoptosis linked to c-FLIP down-regulation selectively in monocytes. Enforced expression of c-FLIP or viral FLIP rescues monocytes from cytotoxicity and concurrently induces potent immun ...[more]