P73 regulates ependymal planar cell polarity by modulating actin and microtubule cytoskeleton.

ABSTRACT: Planar cell polarity (PCP) and intercellular junctional complexes establish tissue structure and coordinated behaviors across epithelial sheets. In multiciliated ependymal cells, rotational and translational PCP coordinate cilia beating and direct cerebrospinal fluid circulation. Thus, PCP disruption results in ciliopathies and hydrocephalus. PCP establishment depends on the polarization of cytoskeleton and requires the asymmetric localization of core and global regulatory modules, including membrane proteins like Vangl1/2 or Frizzled. We analyzed the subcellular localization of select proteins that make up these modules in ependymal cells and the effect of Trp73 loss on their localization. We identify a novel function of the Trp73 tumor suppressor gene, the TAp73 isoform in particular, as

SUBMITTER: Fuertes-Alvarez S 

PROVIDER: S-EPMC6281643 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature