Conserved Transcriptional Signatures in Human and Murine Diabetic Peripheral Neuropathy.

ABSTRACT: Diabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes. In this study, we employed a systems biology approach to identify DPN-related transcriptional pathways conserved across human and various murine models. Eight microarray datasets on peripheral nerve samples from murine models of type 1 (streptozotocin-treated) and type 2 (db/db and ob/ob) diabetes of various ages and human subjects with non-progressive and progressive DPN were collected. Differentially expressed genes (DEGs) were identified between non-diabetic and diabetic samples in murine models, and non-progressive and progressive human samples using a unified analysis pipeline. A transcriptional network for each DEG set was constructed based on literature-derived gene-gene interaction information

SUBMITTER: McGregor BA 

PROVIDER: S-EPMC6281650 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature