Control of non-homeostatic feeding in sated mice using associative learning of contextual food cues.

ABSTRACT: Feeding is a complex motivated behavior controlled by a distributed neural network that processes sensory information to generate adaptive behavioral responses. Accordingly, studies using appetitive Pavlovian conditioning confirm that environmental cues that are associated with food availability can induce feeding even in satiated subjects. However, in mice, appetitive conditioning generally requires intensive training and thus can impede molecular studies that often require large numbers of animals. To address this, we developed and validated a simple and rapid context-induced feeding (Ctx-IF) task in which cues associated with food availability can later lead to increased food consumption in sated mice. We show that the associated increase in food consumption is driven by both positive a

SUBMITTER: Stern SA 

PROVIDER: S-EPMC6281813 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature