Mutations in bacterial genes induce unanticipated changes in the relationship between bacterial pathogens in experimental otitis media.

ABSTRACT: Otitis media (OM) is a common polymicrobial infection of the middle ear in children under the age of 15 years. A widely used experimental strategy to analyse roles of specific phenotypes of bacterial pathogens of OM is to study changes in co-infection kinetics of bacterial populations in animal models when a wild-type bacterial strain is replaced by a specific isogenic mutant strain in the co-inoculating mixtures. As relationships between the OM bacterial pathogens within the host are regulated by many interlinked processes, connecting the changes in the co-infection kinetics to a bacterial phenotype can be challenging. We investigated middle ear co-infections in adult chinchillas (Chinchilla lanigera) by two major OM pathogens: non-typeable Haemophilus influenzae (NTHi) and

SUBMITTER: Lakhani V 

PROVIDER: S-EPMC6281918 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature