Corticosteroids for Graves' Ophthalmopathy: Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Graves' ophthalmopathy (GO) is a complicated autoimmune disease. Various therapies have been used to manage GO; however the optimum therapy is not clear. Glucocorticoids (GCs) therapy is the mainstay of treatment especially for active moderate to severe patients, which needs evidence-based support.

Method

We searched all the randomized controlled trials (RCTs) involving corticosteroid treatment for patients diagnosed with GO from EMBASE, Medline, and the Cochrane library and then conducted a system review and meta-analysis. The electronic search covered the period from April 1966 to March 2018.

Result

Twenty-nine trials were included. GCs were proved to be beneficial for GO patients [response rate, risk ratio (RR) = 1.72, 95% confidence interval (CI): 1.28~

SUBMITTER: Tu X 

PROVIDER: S-EPMC6282115 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature