Effect of IV glyburide on adjudicated edema endpoints in the GAMES-RP Trial.

ABSTRACT:

Objective

In this secondary analysis of the Glyburide Advantage in Malignant Edema and Stroke (GAMES-RP) Trial, we report the effect of IV glyburide on adjudicated, edema-related endpoints.

Methods

Blinded adjudicators assigned designations for hemorrhagic transformation, neurologic deterioration, malignant edema, and edema-related death to patients from the GAMES-RP phase II randomized controlled trial of IV glyburide for large hemispheric infarct. Rates of these endpoints were compared between treatment arms in the per-protocol sample. In those participants with malignant edema, the effects of treatment on additional markers of edema and clinical deterioration were examined.

Results

In the per-protocol sample, 41 patients received glyburide and 36 received placebo.

SUBMITTER: Kimberly WT 

PROVIDER: S-EPMC6282228 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature