Concussion Biomarkers Assessed in Collegiate Student-Athletes (BASICS) I: Normative study.

ABSTRACT:

Objective

To describe variability in concussion biomarker concentrations collected from serum in a sample of healthy collegiate athletes, as well as report reliability metrics in a subsample of female athletes.

Methods

In this observational cohort study, β-amyloid peptide 42 (Aβ₄₂), total tau, S100 calcium binding protein B (S100B), ubiquitin carboxy-terminal hydrolyzing enzyme L1 (UCH-L1), glial fibrillary acidic protein, microtubule associated protein 2, and 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNPase) serum concentrations were measured in 415 (61% male, 40% white, aged 19.0 ± 1.2 years) nonconcussed collegiate athletes without recent exposure to head impacts. Standardized normative distributions are reported for each biomarker. We evaluated main effect

SUBMITTER: Asken BM 

PROVIDER: S-EPMC6282229 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature