USA300 Staphylococcus aureus persists on multiple body sites following an infection.

ABSTRACT:

Background

USA300 methicillin-resistant Staphylococcus aureus (MRSA) is a community- and hospital-acquired pathogen that frequently causes infections but also can survive on the human body asymptomatically as a part of the normal microbiota. We devised a comparative genomic strategy to track colonizing USA300 at different body sites after an initial infection. We sampled ST8 S. aureus from subjects at the site of a first known MRSA infection. Within 60 days of this infection and again 12 months later, each subject was tested for asymptomatic colonization in the nose, throat and perirectal region. 93 S. aureus strains underwent whole genome shotgun sequencing.

Results

Among 28 subjects at the initial sampling time, we isolated S. aureus from the nose, throat and perirectal si

SUBMITTER: Read TD 

PROVIDER: S-EPMC6282268 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature