MicroRNA expression pattern as an ancillary prognostic signature for radiotherapy.

ABSTRACT:

Background

In view of the limited knowledge of plasma biomarkers relating to cancer resistance to radiotherapy, we have set up screening, training and testing stages to investigate the microRNAs (miRNAs) expression profile in plasma to predict between the poor responsive and responsive groups after 6 months of radiotherapy.

Methods

Plasma was collected prior to and after radiotherapy, and the microRNA profiles were analyzed by quantitative reverse transcription polymerase chain reaction (qRT-PCR) arrays. Candidate miRNAs were validated by single qRT-PCR assays from the training and testing set. The classifier for ancillary prognosis was developed by multiple logistic regression analysis to correlate the ratios of miRNAs expression levels with clinical data.

Results

We

SUBMITTER: Li AL 

PROVIDER: S-EPMC6282371 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature