Adenosine A₁ Receptor mRNA Expression by Neurons and Glia in the Auditory Forebrain.

ABSTRACT: In the brain, purines such as ATP and adenosine can function as neurotransmitters and co-transmitters, or serve as signals in neuron-glial interactions. In thalamocortical (TC) projections to sensory cortex, adenosine functions as a negative regulator of glutamate release via activation of the presynaptic adenosine A1 receptor (A₁ R). In the auditory forebrain, restriction of A₁ R-adenosine signaling in medial geniculate (MG) neurons is sufficient to extend LTP, LTD, and tonotopic map plasticity in adult mice for months beyond the critical period. Interfering with adenosine signaling in primary auditory cortex (A1) does not contribute to these forms of plasticity, suggesting regional differences in the roles of A₁ R-mediated adenosine signaling in the foreb

SUBMITTER: Hackett TA 

PROVIDER: S-EPMC6282551 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature