Computational characterization of the binding mode between oncoprotein Ets-1 and DNA-repair enzymes.

ABSTRACT: The Ets-1 oncoprotein is a transcription factor that promotes target gene expression in specific biological processes. Typically, Ets-1 activity is low in healthy cells, but elevated levels of expression have been found in cancerous cells, specifically related to tumor progression. Like the vast majority of the cellular effectors, Ets-1 does not act alone but in association with partners. Given the important role that is attributed to Ets-1 in major human diseases, it is crucial to identify its partners and characterize their interactions. In this context, two DNA-repair enzymes, PARP-1 and DNA-PK, have been identified recently as interaction partners of Ets-1. We here identify their binding mode by means of protein docking. The results identify the interacting surface between Ets-1 and th

SUBMITTER: de Ruyck J 

PROVIDER: S-EPMC6282593 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature