Genomewide Association Study of Leisure-Time Exercise Behavior in Japanese Adults.

ABSTRACT:

Purpose

Although several genetic factors may play a role in leisure-time exercise behavior, there is currently no evidence of a significant genomewide association, and candidate gene replication studies have produced inconsistent results.

Methods

We conducted a two-stage genomewide association study and candidate single-nucleotide polymorphisms (SNP) association study on leisure-time exercise behavior using 13,980 discovery samples from the Japan Multi-Institutional Collaborative Cohort (J-MICC) study, and 2036 replication samples from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center-2 study. Leisure-time physical activity was measured using a self-administered questionnaire that inquired about the type, frequency and duration of exercise. Participant

SUBMITTER: Hara M 

PROVIDER: S-EPMC6282671 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature