The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans.

ABSTRACT:

Aims

To investigate the effect of kisspeptin on glucose-stimulated insulin secretion and appetite in humans.

Materials and methods

In 15 healthy men (age: 25.2 ± 1.1 years; BMI: 22.3 ± 0.5 kg m^-2 ), we compared the effects of 1 nmol kg^-1 h^-1 kisspeptin versus vehicle administration on glucose-stimulated insulin secretion, metabolites, gut hormones, appetite and food intake. In addition, we assessed the effect of kisspeptin on glucose-stimulated insulin secretion in vitro in human pancreatic islets and a human β-cell line (EndoC-βH1 cells).

Results

Kisspeptin administration to healthy men enhanced insulin secretion following an intravenous glucose load, and modulated serum metabolites. In keeping with this, kisspeptin increased glucose-

SUBMITTER: Izzi-Engbeaya C 

PROVIDER: S-EPMC6282711 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature