Something special about CO-dependent CO₂ fixation.

ABSTRACT: Carbon dioxide enters metabolism via six known CO₂ fixation pathways, of which only one is linear, exergonic in the direction of CO₂ -assimilation, and present in both bacterial and archaeal anaerobes - the Wood-Ljungdahl (WL) or reductive acetyl-CoA pathway. Carbon monoxide (CO) plays a central role in the WL pathway as an energy rich intermediate. Here, we scan the major biochemical reaction databases for reactions involving CO and CO₂ . We identified 415 reactions corresponding to enzyme commission (EC) numbers involving CO₂ , which are non-randomly distributed across different biochemical pathways. Their taxonomic distribution, reversibility under physiological conditions, cofactors and prosthetic groups are summarized. In contrast to CO

SUBMITTER: Xavier JC 

PROVIDER: S-EPMC6282760 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature