Methodological recommendations for cognition trials in bipolar disorder by the International Society for Bipolar Disorders Targeting Cognition Task Force.

ABSTRACT:

Objectives

To aid the development of treatment for cognitive impairment in bipolar disorder, the International Society for Bipolar Disorders (ISBD) convened a task force to create a consensus-based guidance paper for the methodology and design of cognition trials in bipolar disorder.

Methods

The task force was launched in September 2016, consisting of 18 international experts from nine countries. A series of methodological issues were identified based on literature review and expert opinion. The issues were discussed and expanded upon in an initial face-to-face meeting, telephone conference call and email exchanges. Based upon these exchanges, recommendations were achieved.

Results

Key methodological challenges are: lack of consensus on how to screen for entry into co

SUBMITTER: Miskowiak KW 

PROVIDER: S-EPMC6282834 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature