NCR3 polymorphism, haematological parameters, and severe malaria in Senegalese patients.

ABSTRACT:

Background

Host factors, including host genetic variation, have been shown to influence the outcome of Plasmodium falciparum infection. Genome-wide linkage studies have mapped mild malaria resistance genes on chromosome 6p21, whereas NCR3-412 polymorphism (rs2736191) lying within this region was found to be associated with mild malaria.

Methods

Blood samples were taken from 188 Plasmodium falciparum malaria patients (76 mild malaria patients, 85 cerebral malaria patients, and 27 severe non-cerebral malaria patients). NCR3-412 (rs2736191) was analysed by sequencing, and haematological parameters were measured. Finally, their association with clinical phenotypes was assessed.

Results

We evidenced an association of thrombocytopenia with both c

SUBMITTER: Thiam A 

PROVIDER: S-EPMC6282937 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature