Overexpression of MCM10 promotes cell proliferation and predicts poor prognosis in prostate cancer.

ABSTRACT:

Background

Prostate cancer (PCa) is one of the most malignant tumors of the male urogenital system. There is an urgent need to identify novel biomarkers for PCa.

Methods

In this study, we evaluated the expression levels of MCM10 in prostate cancer by analyzing public datasets (including The Cancer Genome Atlas and GSE21032). Furthermore, loss of function assays was performed to evaluate the effects of MCM10 on cell proliferation, apoptosis, and colony formation. Furthermore, we performed microarray and bioinformatics analyses to explore the potential mechanisms of MCM10.

Results

In the present study, we for the first time revealed MCM10 was significantly upregulated in PCa. Moreover, we found increased MCM10 expression was significantly associated with advanced clinic

SUBMITTER: Cui F 

PROVIDER: S-EPMC6282949 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature