Mutually Exclusive Cellular Uptake of Combinatorial Supramolecular Copolymers.

ABSTRACT: The cellular uptake of self-assembled biological and synthetic matter results from their multicomponent properties. However, the interplay of the building block composition of self-assembled materials and uptake mechanisms urgently requires addressing. It is shown here that supramolecular polymers that self-assemble in aqueous media, are a modular and controllable platform to modulate cellular delivery by the introduction of small ligands or cationic moieties, with concomitantly different cellular uptake kinetics and valence dependence. A library of supramolecular copolymers revealed stringent mutually exclusive uptake behavior in which either of the uptake pathways dominated, with sharp compositional transition. Supramolecular biomaterial engineering thus provides for adaptive platforms w

SUBMITTER: van Dun S 

PROVIDER: S-EPMC6282950 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature