Correlation of retinal neurodegeneration with measures of peripheral autonomic neuropathy in type 1 diabetes.

ABSTRACT: PURPOSE:To evaluate the relationship of neuroretinal layer thickness with sensitive measures of cardiovascular autonomic neuropathy in diabetic patients with non-proliferative diabetic retinopathy (NPDR). METHODS:Twenty-seven eyes of 27 patients with type 1 diabetes presenting with mild-to-moderate NPDR were compared to 27 healthy control (HC) eyes matched for age and gender. The total macular volume (TMV) and the volumes of individual neurosensory layers in the macula were analysed from spectral domain optical coherence tomography using automated layer segmentation. Cardiovascular autonomic regulation was assessed by short-term power spectrum analysis of heart rate variability (HRV) before, during and after an orthostatic challenge. RESULTS:The patients had an age of 46 ± 12 years and dia

SUBMITTER: Pemp B 

PROVIDER: S-EPMC6282971 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature