Genetic Dissection of Hybrid Male Sterility Across Stages of Spermatogenesis.

ABSTRACT: Hybrid sterility is a common form of reproductive isolation between nascent species. Although hybrid sterility is routinely documented and genetically dissected in speciation studies, its developmental basis is rarely examined, especially in generations beyond the F₁ generation. To identify phenotypic and genetic determinants of hybrid male sterility from a developmental perspective, we characterized testis histology in 312 F₂ hybrids generated by intercrossing inbred strains of Mus musculus domesticus and M. m. musculus, two subspecies of house mice. Hybrids display a range of histologic abnormalities that indicate defective spermatogenesis. Among these abnormalities, we quantified decreased testis size, reductions in spermatocyte and spermatid number,

SUBMITTER: Schwahn DJ 

PROVIDER: S-EPMC6283182 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature