A practical guide to pre-trial simulations for Bayesian adaptive trials using SAS and BUGS.

ABSTRACT: It is often unclear what specific adaptive trial design features lead to an efficient design which is also feasible to implement. Before deciding on a particular design, it is generally advisable to carry out a simulation study to characterise the properties of candidate designs under a range of plausible assumptions. The implementation of such pre-trial simulation studies presents many challenges and requires considerable statistical programming effort and time. Despite the scale and complexity, there is little existing literature to guide the implementation of such projects using commonly available software. This Teacher's Corner article provides a practical step-by-step guide to implementing such simulation studies including how to specify and fit a Bayesian model in WinBUGS or OpenBUGS

SUBMITTER: Hansen CH 

PROVIDER: S-EPMC6283249 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature