Comparative Secretome Analyses of Primary Murine White and Brown Adipocytes Reveal Novel Adipokines.

ABSTRACT: The adipose organ, including white and brown adipose tissues, is an important player in systemic energy homeostasis, storing excess energy in form of lipids while releasing energy upon various energy demands. Recent studies have demonstrated that white and brown adipocytes also function as endocrine cells and regulate systemic metabolism by secreting factors that act locally and systemically. However, a comparative proteomic analysis of secreted factors from white and brown adipocytes and their responsiveness to adrenergic stimulation has not been reported yet. Therefore, we studied and compared the secretome of white and brown adipocytes, with and without norepinephrine (NE) stimulation. Our results reveal that carbohydrate-metabolism-regulating proteins are preferably secreted from white

SUBMITTER: Ali Khan A 

PROVIDER: S-EPMC6283297 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature