Comparative Secretome Analyses of Human and Zoonotic <i>Staphylococcus aureus</i> Isolates CC8, CC22, and CC398.

ABSTRACT: The spread of methicillin-resistant Staphylococcus aureus (MRSA) in the community, hospitals and in livestock is mediated by highly diverse virulence factors that include secreted toxins, superantigens, enzymes and surface-associated adhesins allowing host adaptation and colonization. Here, we combined proteogenomics, secretome and phenotype analyses to compare the secreted virulence factors in selected S. aureus isolates of the dominant human- and livestock-associated genetic lineages CC8, CC22, and CC398. The proteogenomic comparison revealed 2181 core genes and 1306 accessory genes in 18 S. aureus isolates reflecting the high genome diversity. Using secretome analysis, we identified 869 secreted proteins with 538 commons in eight isolates of CC8, CC22, and CC398. Th

SUBMITTER: Busche T 

PROVIDER: S-EPMC6283302 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature