Progesterone-Mediated Inhibition of the GnRH Pulse Generator: Differential Sensitivity as a Function of Sleep Status.

ABSTRACT:

Context

During normal, early puberty, luteinizing hormone (LH) pulse frequency is low while awake but increases during sleep. Mechanisms underlying such changes are unclear, but a small study in early pubertal girls suggested that differential wake-sleep sensitivity to progesterone negative feedback plays a role.

Objective

To test the hypothesis that progesterone acutely reduces waking LH pulse frequency more than sleep-associated pulse frequency in late pubertal girls.

Design

Randomized, placebo-controlled, double-blinded crossover study.

Setting

Academic clinical research unit.

Participants

Eleven normal, postmenarcheal girls, ages 12 to 15 years.

Intervention

Subjects completed two 18-hour admissions in separate menstrual cycles (cycle days 6 t

SUBMITTER: Kim SH 

PROVIDER: S-EPMC6283412 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature