Normalized Early Postoperative Cortisol and ACTH Values Predict Nonremission After Surgery for Cushing Disease.

ABSTRACT:

Context

Perioperative increases in adrenocorticotropic hormone (ACTH) and cortisol mimic results of corticotropin-releasing hormone (CRH) stimulation testing. This phenomenon may help identify patients with residual adenoma after transsphenoidal surgery (TSS) for Cushing disease (CD).

Objective

To predict nonremission after TSS for CD.

Design

Retrospective case-control study of patients treated at a single center from December 2003 until July 2016. Early and medium-term remission were assessed at 10 days and 11 months.

Patients and setting

Two hundred and ninety-one consecutive TSS cases from 257 patients with biochemical evidence of CD seen at a clinical center.

Interventions

Normalized early postoperative values (NEPVs) for cortisol and ACTH were calcu

SUBMITTER: Asuzu D 

PROVIDER: S-EPMC6283430 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature