Body Composition and Ectopic Lipid Changes With Biochemical Control of Acromegaly.

ABSTRACT:

Context

Acromegaly is characterized by growth hormone (GH) and insulinlike growth factor-1 (IGF-1) hypersecretion, and GH and IGF-1 play important roles in regulating body composition and glucose homeostasis.

Objective

The purpose of our study was to investigate body composition including ectopic lipids, measures of glucose homeostasis, and gonadal steroids in patients with active acromegaly compared with age-, body mass index (BMI)-, and sex-matched controls and to determine changes in these parameters after biochemical control of acromegaly.

Design

Cross-sectional study of 20 patients with active acromegaly and 20 healthy matched controls. Prospective study of 16 patients before and after biochemical control of acromegaly.

Main outcome measures

Body compositi

SUBMITTER: Bredella MA 

PROVIDER: S-EPMC6283448 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature