The impact of a fine-scale population stratification on rare variant association test results.

ABSTRACT: Population stratification is a well-known confounding factor in both common and rare variant association analyses. Rare variants tend to be more geographically clustered than common variants, because of their more recent origin. However, it is not yet clear if population stratification at a very fine scale (neighboring administrative regions within a country) would lead to statistical bias in rare variant analyses. As the inclusion of convenience controls from external studies is indeed a common procedure, in order to increase the power to detect genetic associations, this problem is important. We studied through simulation the impact of a fine scale population structure on different rare variant association strategies, assessing type I error and power. We showed that principal component a

SUBMITTER: Persyn E 

PROVIDER: S-EPMC6283567 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature