Loop diuretic adjustments in patients with chronic heart failure: Insights from HF-ACTION.

ABSTRACT:

Background

The relationship between diuretic use or change in diuretic use and outcomes in chronic heart failure (HF) remains poorly defined. We evaluated the association between diuretic use and changes in health status, exercise capacity, and clinical events in a large randomized trial of subjects with HF.

Methods

HF-ACTION randomized 2,331 outpatients with HF and ejection fraction ≤35% to aerobic exercise training versus usual care. We grouped patients according to loop diuretic use from baseline through 6 months: continued use, never use, initiated, and discontinued. The association between diuretic use and changes in health status, exercise capacity, and clinical outcomes (all-cause mortality/hospitalization, cardiovascular mortality, and HF hospitalization) through 12 

SUBMITTER: Fudim M 

PROVIDER: S-EPMC6283675 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature