Effects of red blood cell (RBC) transfusion on sickle cell disease recipient plasma and RBC metabolism.

ABSTRACT:

Background

Exchange transfusion is a mainstay in the treatment of sickle cell anemia. Transfusion recipients with sickle cell disease (SCD) can be transfused over 10 units per therapy, an intervention that replaces circulating sickle red blood cells (RBCs) with donor RBCs. Storage of RBCs makes the intervention logistically feasible. The average storage duration for units transfused at the Duke University Medical Center is approximately 2 weeks, a time window that should anticipate the accumulation of irreversible storage lesion to the RBCs. However, no metabolomics study has been performed to date to investigate the impact of exchange transfusion on recipients' plasma and RBC phenotypes.

Study design and methods

Plasma and RBCs were collected from patients with sickle cell

SUBMITTER: Culp-Hill R 

PROVIDER: S-EPMC6283695 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature