Harnessing the potential of therapeutic agents to safeguard bone health in prostate cancer.

ABSTRACT:

Background

Patients with prostate cancer are at risk of impaired bone health. Prostate cancer has a propensity to metastasize to bone, after which patients are at risk of skeletal-related events (SREs). These complications are associated with increased mortality, substantial pain, and reduced quality of life. Patients are also at risk of bone loss due to androgen deprivation therapy (ADT), which can be compounded in elderly patients with reduced bone density. It is essential, therefore, that aspects of bone health and therapies able to prevent the occurrence of SREs are considered throughout the clinical course of prostate cancer.

Methods

We reviewed the literature regarding the molecular mechanisms underpinning bone lesion formation, the modes of action of therapies that pr

SUBMITTER: Miller K 

PROVIDER: S-EPMC6283859 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature