A novel and safe small molecule enhances hair follicle regeneration by facilitating metabolic reprogramming.

ABSTRACT: Targeting hair follicle regeneration has been investigated for the treatment of hair loss, and fundamental studies investigating stem cells and their niche have been described. However, knowledge of stem cell metabolism and the specific regulation of bioenergetics during the hair regeneration process is currently insufficient. Here, we report the hair regrowth-promoting effect of a newly synthesized novel small molecule, IM176OUT05 (IM), which activates stem cell metabolism. IM facilitated stemness induction and maintenance during an induced pluripotent stem cell generation process. IM treatment mildly inhibited mitochondrial oxidative phosphorylation and concurrently increased glycolysis, which accelerated stemness induction during the early phase of reprogramming. More importantly, the t

SUBMITTER: Son MJ 

PROVIDER: S-EPMC6283868 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature